Lactobacillus rhamnosus Hsryfm 1301 Fermented Milk Regulates Lipid Metabolism and Inflammatory Response in High-Fat Diet Rats

A rat model of disordered lipid metabolism was established to study the regulation and inflammatory response by Lactobacillus rhamnosus hsryfm 1301 fermented milk. The results showed that high-fat diet caused disorder in rats, accompanied occurrence an response. After milk intervention, blood level reduced along with activity aspartate aminotransferase (AST) alanine (ALT) as well triglyceride (TG) total cholesterol (TC) contents liver rats (p < 0.05), fat vacuoles hepatocytes were reduced, accumulation decreased. Liver injury restored. Meanwhile, levels free fatty acid (FFA) synthase (FAS), acetyl coenzyme carboxylase (ACC), lipoprotein esterase (LPL) hepatic lipase (HL) serum significantly lower than those group which indicated synthesis inhibited, production restored balance. In addition, reactive oxygen species (ROS) factors also could not only inhibit but reduce excessive acids, thus reducing accumulation, restoring balance alleviating rats. At same time, it can ROS through antioxidant effect, alleviate response, metabolism.